果冻影院 Genetics Institute Research Theme Human Disease and Cancer 鈥� 果冻影院

Human Disease and Cancer

Understanding genetic architecture and how changes in the human genome may link to disease phenotypes is fundamental in order to gain mechanistic insights into the causes of complex malignancies such as cancer or neurodegenerative diseases.

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A major focus of our research is developing new quantitative methods to identify variants linked to disease, as well as to build predictive models of disease emergence or response to therapy. To tackle these complex questions, we apply multiple statistical and computational strategies with focus on:

Leveraging unique characteristics of different populations in order to identify genetic and environmental risk factors of complex diseases such as cancer, cardiovascular disease or depressive disorders ()
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Developing improved statistical methods for the genetic analysis of rare and common diseases, such as schizophrenia ()
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Making use of the rich information contained in electronic health records to generate clinically actionable insights ()
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Employing machine learning and data integration approaches to shed light into regulatory mechanisms and progression of cancer ().