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This module gives an introduction to anatomy and development of motoneurons and neuromuscular junctions, the development of different motoneuron types leading to differences in their physiology and functional characteristics. The course also gives an overview of the most important diseases that affect either the neuromuscular junction or motor neurons and lead to diseases affecting the motor system as a whole, including motoneuron disease (MND), Spinobulbar Muscular Atrophy (SBMA) and rare diseases of the neuromuscular junction, such as Myasthenia Gravis.

This module aims to give you a sound understanding of the anatomy and function of spinal motoneurons and neuromuscular junctions and a comprehensive overview of the clinical features and scientific understanding of diseases affecting motoneurons and neuromuscular junctions.

By the end of this course you will understand the anatomy, development and functional characteristics of different spinal motoneuron subtypes and their interdependence with innervated muscles for the maintenance of intact neuromuscular junctions and correct functioning of the neuromuscular system. You will also be able to understand the underlying pathology, genetic background and current research trends in motoneuron diseases and diseases of neuromuscular junctions. You will be able to understand and interpret neurophysiological assessments and characteristic histopathology in neuromuscular junction diseases; you will be able to critically evaluate the validity of disease models for the development of future therapies and to understand the difficulties designing clinical trials in NMD.Ìý