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Description
This module focuses on how the immune system can cause pathology by mounting undesired responses to self-tissues. It is currently unclear why in about 5% of individuals there is a breakdown in the immunological tolerance mechanisms that normally prevent harmful immunity to our own body constituents.
We will explore the genetics and immune mechanisms underlying these responses, as revealed both by mechanistic studies in mouse models of autoimmunity and from clinical settings, studying diseases in human populations. A number of organ-specific and systemic autoimmune conditions will be covered in detail, as well as a range of relevant animal models of autoimmunity that have led to a better understanding of immune mechanisms. This study of clinical and experimental immunology will illuminate the contribution of the various components of the immune system to the destructive process responsible for disease and understand how modern immune interventions target different stages of disease development.
The module includes a formative 鈥楧ata Interpretation鈥� assessment based upon analysis of a research paper. In-course summative assessment comprises an expansive essay drawing on broad knowledge of autoimmune processes.
Learning outcomes
By the end of the module, you will have a deep understanding of the immunopathology underlying a number of systemic and organ specific autoimmune diseases in humans, including systemic lupus erythematosus, rheumatoid arthritis, type I diabetes and multiple sclerosis. You will appreciate how relevant animal models help us understand the aetiology of such AIDs and how such knowledge underpins the latest immunotherapeutic approaches to treatment and prevention of these diseases.
Module deliveries for 2024/25 academic year
Last updated
This module description was last updated on 8th April 2024.
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