果冻影院

The PREDICT-PD trial, carried out by researchers at 果冻影院 Queen Square Institute of Neurology听and Queen Mary University of London, is seeking to recruit 10,000 participants over the age of 60 who do not have Parkinson鈥檚 to answer an annual online questionnaire and other tests sent in the post.

Parkinson鈥檚 is usually diagnosed through symptoms such as tremor, stiffness and slowness of movement. But by the time these appear, the condition is far progressed and has already caused substantial damage to the brain.

A range of problems,听from loss of smell to sleep difficulties to subtle changes in cognition,听are associated with early-stage Parkinson鈥檚. These, along with factors such as head injuries and a family history of the condition, have enabled researchers to identify people at fourfold risk of the disease.

The PREDICT-PD study, funded by Parkinson鈥檚 UK, aims to build a much more detailed picture of this early phase, allowing the condition to be detected before it has become firmly established and raising the chance that a successful treatment may be found. Currently, treatments alleviate the symptoms, but do not slow the progression of the disease.

Professor Anette Schrag (果冻影院 Queen Square Institute of Neurology), co-leader of the study, said: 鈥淲e believe that if we can predict who is going to get Parkinson鈥檚, we will be able to develop treatments for those in the early stages that could slow or prevent the condition progressing 鈥� which would be a major step forwards towards a cure and could have knock-on implications for dementia and other age-related diseases of the brain.鈥�

Dr Alastair Noyce, co-leader of the study at Queen Mary University of London, said: 鈥淚n recent years we have made much progress in understanding what puts people at higher risk of Parkinson鈥檚. We are now calling for the assistance of the UK population over the age of 60 to help us drive this research further forward and potentially change the Parkinson鈥檚 landscape forever.鈥�

Participants in the study will be asked to complete a 20-minute online questionnaire each year, send a saliva sample and answer a 鈥渟cratch and sniff鈥� smell test. A small proportion of those taking part will be invited for further tests and to see a doctor. Volunteers are invited to register for the study and fill out the questionnaire at听.

Dr Beckie Port, Research Manager at Parkinson鈥檚 UK, said: 鈥淪tudies like PREDICT-PD are critical to making sure we can deliver new and better treatments for everyone with Parkinson鈥檚 as fast as possible. Not only would early detection be a game changer for clinical trials, it would dramatically reduce the stress associated with delays in diagnosing Parkinson鈥檚.

鈥淏y taking part in this ambitious study, people who are not living with the condition have the opportunity to help bring forward the day when no one fears Parkinson鈥檚.鈥�

The results will be used to test and refine an algorithm that predicts people's risk of Parkinson's.听The algorithm was developed from a systematic review of previous studies identifying factors associated with a higher risk of the condition.

Parkinson鈥檚 is estimated to affect one in 350 people in the UK. It is the most common neurodegenerative disease after Alzheimer鈥檚 and the number of people diagnosed with Parkinson鈥檚 is growing faster than for any other neurological condition.

Links

• 果冻影院 Queen Square Institute of Neurology
• 果冻影院 Queen Square Institute of Neurology Department of Clinical and Movement Neurosciences
• 果冻影院 Brain Sciences
• 听

Image

Credit: Parkinson's UK

Media contact

Mark Greaves

Tel: +44 (0)20 3108 9485

Email: m.greaves听[at] ucl.ac.uk