果冻影院

The findings, published in Neuron, demonstrate for the first time in humans that two neurochemicals best known for their roles in reward processing also integrate people鈥檚 perceptions of the world with their actions.

With their discovery, the UK-US research team demonstrated that it is possible to continually and simultaneously measure the activity of both dopamine and serotonin 鈥攚hose receptor and uptake sites are therapeutic targets for disorders ranging from depression to Parkinson鈥檚 disease 鈥� in the human brain.

Lead author Dr Dan Bang (Wellcome Centre for Human Neuroimaging, 果冻影院 Queen Square Institute of Neurology). 鈥淲e鈥檝e thought that dopamine and serotonin at these fast time scales are solely involved in reward processing 鈥� or how good or how bad an outcome is after taking an action. What we show here is that these neuromodulators play a much broader role in supporting human behaviour and thought, and in particular that they are involved in how we process the outside world.

鈥淔or example, if you move through a room and the lights are off, you move differently because you鈥檙e uncertain about where objects are. Our work suggests these neuromodulators 鈥� serotonin in particular鈥� are playing a role in signalling how uncertain we are about the outside environment.鈥�

Studies in animals have previously indicated that dopamine and serotonin may be involved in perceptual decision-making, but researchers had been unable to study this in people due to challenges in studying the neurotransmitters at fast time scales.

鈥淣euromodulatory systems, involving dopamine and serotonin that broadcast chemicals throughout the brain, are difficult to study in humans. We can examine the effects of drugs such as antidepressants that have neuromodulatory effects, but drugs are slow-acting and diffuse 鈥� they do not tell us how fast changes in neuromodulator levels in specific parts of the brain impact thought and behaviour,鈥� explained Dr Bang.

But now, in first-ever measurements, scientists used an electrochemical method called 鈥渇ast scan cyclic voltammetry,鈥� which employs a small carbon fiber microelectrode that has low voltages ramped across it for real-time detection of dopamine and serotonin activity.

In the study, researchers recorded fluctuations in dopamine and serotonin using specially designed electrodes in five patients undergoing deep brain stimulation electrode implantation surgery to treat essential tremor or Parkinson鈥檚 disease. Patients were awake during surgery, playing a computer game designed to quantify aspects of thought and behaviour while the measurements were taken.

On each round of the game, patients briefly viewed a cloud of dots and were asked to judge the direction they were moving. The method, designed by Dr Bang and 果冻影院 colleague Dr Steve Fleming, helped indicate that dopamine and serotonin were involved in simple perceptual decisions, outside of the traditional context of rewards and losses.

The researchers found that in one part of a brain region called the striatum (specifically, the caudate nucleus), serotonin levels rapidly increased when uncertainty was high. In another part of the striatum, the putamen, both dopamine and serotonin were found to trigger the action that indicated a patient鈥檚 decision. Dopamine levels rapidly increased prior to an action (akin to 鈥榩ressing the accelerator鈥�), whereas serotonin levels rapidly decreased (akin to 鈥榬eleasing the brake鈥�).

Better understanding of the underlying actions of dopamine and serotonin during perception and decision-making could deliver important insight into psychiatric and neurological disorders, the researchers said.

Senior author Professor P. Read Montague (Virginia Tech Carilion and honorary professor, 果冻影院 Queen Square Institute of Neurology) said: 鈥淎n enormous number of people throughout the world are taking pharmaceutical compounds to perturb the dopamine and serotonin transmitter systems to change their behaviour and mental health.

鈥淔or the first time, moment-to-moment activity in these systems has been measured and determined to be involved in perception and cognitive capacities. These neurotransmitters are simultaneously acting and integrating activity across vastly different time and space scales than anyone expected.鈥�

Co-lead author Dr Kenneth Kishida (Wake Forest School of Medicine) added: 鈥淓very choice that someone executes involves taking in information, interpreting that information, and making decisions about what they perceived. There鈥檚 a whole host of psychiatric conditions and neurological disorders where that process is altered in the patients, and dopamine and serotonin are prime suspects.鈥�

The research was funded by Wellcome and the National Institutes of Health.

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