果冻影院

Working with seven UK hospitals, including the National Hospital for Neurology and Neurosurgery, part of 果冻影院H, 119 patients with glioblastoma have been recruited in just over two years to the IPI-GLIO trial.听

The trial is designed by Dr Paul Mulholland, who leads the 果冻影院 Glioblastoma Research Group, and has been funded by the National Brain Appeal and supported by the 果冻影院H NIHR Biomedical Research Centre.

Glioblastoma is a very aggressive brain tumour with around 2,200 cases diagnosed each year in England (and around 3,200 across the UK). The average survival time is around 15 months, with fewer than 10 per cent of patients alive five years after diagnosis following standard treatment.

In the Phase II Clinical trial, following standard treatment for glioblastoma of surgery (where appropriate), radiotherapy and chemotherapy, patients were given ipilimumab, a drug that has seen significant improvements in survival rates for people with melanoma skin cancer. The drug blocks a key regulator in the immune system, making the immune system more active.

Study participants will be followed up over the next 18 months and the findings will be presented to the American Society of Clinical Oncology in May 2023.

Chief Investigator, Dr Mulholland (果冻影院 Cancer Institute and consultant medical oncologist at 果冻影院H), said: 鈥淚t cannot be underestimated how significant The National Brain Appeal鈥檚 decision to fundraise for this trial has been. I am so grateful to everyone who has donated and those continuing to fundraise.鈥�

The IPI-GLIO trial represents the UK鈥檚 first large scale, charitably funded, immunotherapy trial for NHS patients recently diagnosed with glioblastoma brain cancer; the patient cohort is the largest ever number of UK participants in a brain cancer clinical trial.

It is sponsored and managed by the University of Oxford. The pharmaceutical company Bristol Myers Squibb also contributed to part funding the study and provide the drug ipilimumab.

Looking beyond this trial, Dr Mulholland continued: 鈥淣ow that we have recruited the 119 patients to the IPI-GLIO trial we have planned a programme of trials so this work can continue. We have established a Glioblastoma Research Group and laboratory at 果冻影院 Cancer Institute. We are bringing together the newest drugs from the pharmaceutical industry together with the latest developments in scientific research to try to find a cure for this devastating disease.鈥�

Funds raised by the charity have enabled the trial to take place in seven centres around the UK, in Cambridge, Edinburgh, London (果冻影院H and Guy鈥檚 Hospital), Manchester, Middlesex and Oxford.

Links

• 果冻影院 Glioblastoma Research Group
• 果冻影院 Cancer Institute

Image

• Glioblastoma. Credit: Wikicommons

Media contact

Henry Killworth

Tel: +44 (0) 7881 833274

E: h.killworth [at] ucl.ac.uk