果冻影院

The Trial of Ondansetron as a Parkinson鈥檚 HAllucinations Treatment, or TOP HAT study, is now recruiting volunteers across England, Scotland and Wales to evaluate whether ondansetron, an anti-sickness drug used in the NHS for cancer patients, could also be used for treating hallucinations in people with听Lewy body dementia听or听Parkinson鈥檚 disease.

Hallucinations听affect up to 75% of people with Parkinson鈥檚 and Lewy body dementia at some point during their condition. They can be extremely distressing and sometimes result in a person becoming confused, frightened, or in need of support.

Current hallucination medications also negatively affect other Parkinson鈥檚 and Lewy body dementia symptoms, so research into new treatments is vital.

Ondansetron has previously shown promise for treating hallucinations and with the drug already being used in the NHS, dementia researchers are excited to explore its full potential.

Chief investigator Professor Suzanne Reeves (果冻影院 Psychiatry) said: 鈥淐urrent drug treatment options for visual hallucinations in people with Parkinson鈥檚 disease and Lewy body dementia are limited and can cause significant side effects which worsen some people鈥檚 symptoms.

鈥淚t is really important that we identify and test alternative treatments, and given that ondansetron is already used in the NHS, it鈥檚 possible we could have an effective treatment available in a fraction of the usual time.鈥�

Dr Beckie Port, Head of Research at听Parkinson鈥檚 UK, added: 鈥淲hile most people will be familiar with the motor symptoms of Parkinson鈥檚, like tremor and slowness, non-motor symptoms like pain, sleep problems and hallucinations are very common.

鈥淗allucinations can have a huge impact on quality of life and can be incredibly distressing for the individual and their loved ones, so this research is a really positive step forward to finding more effective treatments.鈥�

TOP HAT is a rapidly expanding phase II clinical trial funded by Parkinson鈥檚 UK. There are approximately 30 study sites open in England, Scotland and Wales, with many more due to open soon to enable the research team to recruit 216 study participants.

If chosen for the study, participants will be randomly allocated to receive ondansetron, the study drug, or the placebo (a dummy drug). TOP HAT is a double-blind study, which means neither participants or the clinical team prescribing the study drug and placebo will know which treatment is being taken.

Participants will be able to take all of the medication for this study at home, as the study drug or placebo will be delivered directly to their address with clear instructions on how to take them.

The study lasts for approximately 24 weeks. Participants will take the study drug or placebo tablets for 12 weeks and there will be further follow-ups for 12 weeks after they finish taking the medication.

During the study, people will be asked to complete a range of study assessments, including questions about hallucinations and any other symptoms they are experiencing, and how they impact on quality of life.

Links

• More information about the TOPHAT trial
• 果冻影院 Psychiatry

Source

Image

• Pills. Source: Fabio Hofnik on听听(CC BY-ND 2.0)

Media contact

Chris Lane

Tel: +44 (0)20 7679 9222

Email: chris.lane [at] ucl.ac.uk